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Single-Cell 3D Genome

SCL: A lattice-based approach to infer three-dimensional chromosome structures from single-cell Hi-C data. On the right, SCL-inferred 3D structure of single-cell human (GM12878) inactivated X-chromosome.


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Family Classification of TADs

TADKB: Family classification and a knowledge base of topologically associating domains. On the right, multiple TADs are highlighted in the 3D structure of human chromosome 10.


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Enhance Hi-C data resolution

HiCNN: A very deep convolutional neural network to better enhance the resolution of Hi-C data. On the right, black circle indicates a chromatin interaction that is revealed after enhancement.


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