Z. WANG LAB
Single-Cell 3D Genome
SCL: A lattice-based approach to infer three-dimensional chromosome structures from single-cell Hi-C data. On the right, SCL-inferred 3D structure of single-cell human (GM12878) inactivated X-chromosome.
Family Classification of TADs
TADKB: Family classification and a knowledge base of topologically associating domains. On the right, multiple TADs are highlighted in the 3D structure of human chromosome 10.
Enhance Hi-C data resolution
HiCNN: A very deep convolutional neural network to better enhance the resolution of Hi-C data. On the right, black circle indicates a chromatin interaction that is revealed after enhancement.